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Aldo Nicolás Leal Egaña

Group Leader

Heidelberg University

Heidelberg, Alemania

My research is focused on developing and using polymer-based scaffolds for studying and improving tissue repair and wound healing processes, as well as creating pathology-like environments (i.e. cancer; tumor-like platforms). To this purpose, I use methodological tools developed by the biochemistry, cell biology, nanotechnology and biophysics, in order to accurately mimic in vitro the in vivo milieu.

Biotechnology, Biomaterials, Tissue Engineering, Leipzig University. Alemania, 2009
Biochemical Engineering, Pontificia Universidad Católica de Valparaíso. Chile, 2002
Biochemist, Universidad de Chile. Chile, 2001

Group Leader Full Time

Heidelberg University

IMSEAM

Alemania

2001 - A la fecha

PhD student

BioCity - University of Leipzig

Leipzig, Alemania

2004 - 2007
Pre-doctoral researcher

TRM - University of Leipzig

Leipzig, Alemania

2007 - 2008
Post-doctoral researcher

University of Bayreuth

Bayreuth, Alemania

2008 - 2012
Guest researcher

University of Erlangen-Nürnberg

Erlangen, Alemania

2012 - 2012
Post-doctoral researcher

CEA research institute

Grenoble, Francia

2012 - 2014
Research associate

University of Glasgow

Glasgow, Reino Unido

2014 - 2016
Group Leader Full Time

Heidelberg University

Heidelberg, Alemania

2001 - A la fecha


Blood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-β1 signaling mechanism Gorodetska, Ielizaveta; Lukiyanchuk, Vasyl; Gawin, Marta; Sliusar, Myroslava; Linge, Annett; Lohaus, Fabian; Hoelscher, Tobias; Erdmann, Kati; Fuessel, Susanne; Borkowetz, Angelika; et al. Article ISI JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2025)
In Situ Fabrication of Constraints for Multicellular Micro-Spheroids Using Two-Photon Lithography Taale, Mohammadreza; Schamberger, Barbara; Taheri, Fereydoon; Antonelli, Yasmin; Leal-Egana, Aldo; Selhuber-Unkel, Christine Article ISI ADVANCED FUNCTIONAL MATERIALS (2024)
Levofloxacin loaded poly (ethylene oxide)-chitosan/quercetin loaded poly (D,L-lactide-co-glycolide) core-shell electrospun nanofibers for burn wound healing Monavari, Mahshid; Sohrabi, Razieh; Motasadizadeh, Hamidreza; Monavari, Mehran; Fatahi, Yousef; Ejarestaghi, Negin Mousavi; Fuentes-Chandia, Miguel; Leal-Egana, Aldo; Akrami, Mohammad; Homaeigohar, Shahin Article ISI FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2024)
When Mechanical Stress Matters: Generation of Polyploid Giant Cancer Cells in Tumor-Like Microcapsules Antonelli, Yasmin; Krueger, Rene; Buehler, Adrian; Monavari, Mahshid; Fuentes-Chandia, Miguel; Colombo, Federico; Palmisano, Ralf; Bosserhoff, Anja K.; Kappelmann-Fenzl, Melanie; Schoedel, Johannes; et al. Article ISI ADVANCED FUNCTIONAL MATERIALS (2024)
Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma Ramesh, Vignesh; Gollavilli, Paradesi Naidu; Pinna, Luisa; Siddiqui, Mohammad Aarif; Turtos, Adriana Martinez; Napoli, Francesca; Antonelli, Yasmin; Leal-Egana, Aldo; Havelund, Jesper Foged; Jakobsen, Simon Toftholm; et al. Article ISI EMBO MOLECULAR MEDICINE (2023)
Topical systems for the controlled release of antineoplastic Drugs: Oxidized Alginate-Gelatin Hydrogel/Unilamellar vesicles Stagnoli, Soledad; Garro, Cintia; Ertekin, Ozlem; Heid, Susanne; Seyferth, Stefan; Soria, Gaston; Correa, N. Mariano; Leal-Egana, Aldo; Boccaccini, Aldo R. Article ISI JOURNAL OF COLLOID AND INTERFACE SCIENCE (2023)
3D hydrogel-based microcapsules as an<i> in vitro</i> model to study tumorigenicity, cell migration and drug resistance Ertekin, Oezlem; Monavari, Mahshid; Krueger, Rene; Fuentes-Chandia, Miguel; Parma, Beatrice; Letort, Gaelle; Tripal, Philipp; Boccaccini, Aldo R.; Bosserhoff, Anja K.; Ceppi, Paolo; et al. Article ISI ACTA BIOMATERIALIA (2022)
3D Spheroids Versus 3D Tumor-Like Microcapsules: Confinement and Mechanical Stress May Lead to the Expression of Malignant Responses in Cancer Cells Fuentes-Chandia, Miguel; Vierling, Andreas; Kappelmann-Fenzl, Melanie; Monavari, Mahshid; Letort, Gaelle; Hoene, Lucas; Parma, Beatrice; Antara, Sharmin Khan; Ertekin, Oezlem; Palmisano, Ralph; et al. Article ISI ADVANCED BIOLOGY (2021)
Integration of Mesoporous Bioactive Glass Nanoparticles and Curcumin into PHBV Microspheres as Biocompatible Composite for Drug Delivery Applications Aguilar-Rabiela, Arturo E.; Leal-Egana, Aldo; Nawaz, Qaisar; Boccaccini, Aldo R. Article ISI MOLECULES (2021)
Silibinin releasing mesoporous bioactive glass nanoparticles with potential for breast cancer therapy Nawaz, Qaisar; Fuentes-Chandia, Miguel; Tharmalingam, Varun; Rehman, Muhammad Atiq Ur; Leal-Egana, Aldo; Boccaccini, Aldo R. Article ISI CERAMICS INTERNATIONAL (2020)
Novel approach for the assessment of ovarian follicles infiltration in polymeric electrospun patterned scaffolds Raffel, Nathalie; Dittrich, Ralf; Baeuerle, Tobias; Seyler, Lisa; Fattahi, Amir; Hoffmann, Inge; Leal-Egana, Aldo; Beckmann, Matthias W.; Boccaccini, Aldo R.; Liverani, Liliana Article ISI PLOS ONE (2019)
Engineered Coatings for Titanium Implants To Present Ultralow Doses of BMP-7 Al-Jarsha, Mohammed; Moulisova, Vladimira; Leal-Egana, Aldo; Connell, Andrew; Naudi, Kurt B.; Ayoub, Ashraf F.; Dalby, Matthew J.; Salmeron-Sanchez, Manuel Article ISI ACS BIOMATERIALS SCIENCE & ENGINEERING (2018)
Facile Photochemical Modification of Silk Protein-Based Biomaterials Hardy, John G.; Bertin, Annabelle; Torres-Rendon, Jose Guillermo; Leal-Egana, Aldo; Humenik, Martin; Bauer, Felix; Walther, Andreas; Coelfen, Helmut; Schlaad, Helmut; Scheibel, Thomas R. Article ISI MACROMOLECULAR BIOSCIENCE (2018)
The size-speed-force relationship governs migratory cell response to tumorigenic factors Leal-Egana, Aldo; Letort, Gaelle; Martiel, Jean-Louis; Christ, Andreas; Vignaud, Timothee; Roelants, Caroline; Filhol, Odile; Thery, Manuel Article ISI MOLECULAR BIOLOGY OF THE CELL (2017)
Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering Hardy, John; Torres-Rendon, Jose; Walther, Andreas; Schlaad, Helmut; Clfen, Helmut; Scheibel, Thomas Article MATERIALS (2016)
Measurement of cell traction forces with ImageJ Martiel JL, Leal A, Kurzawa L, Balland M, Wang I, Vignaud T, Tseng Q, Théry M. Article ISI article. DOI: 10.1016/bs.mcb.2014.10.008 Methods in Cell Biology (2015)
Sensing the Difference: The Influence of Anisotropic Cues on Cell Behavior Ballester-Beltrn, Jos; Biggs, Manus J. P.; Dalby, Matthew J.; Salmern-Snchez, Manuel Article FRONTIERS IN MATERIALS (2015)
Glycopolymer Functionalization of Engineered Spider Silk Protein-based Materials for Improved Cell Adhesion Hardy, John G.; Pfaff, Andr; Mller, Axel H. E.; Scheibel, Thomas R. Article Macromolecular Bioscience (2014)
Engineered Spider Silk Protein-Based Composites for Drug Delivery Hardy, John G.; Scheibel, Thomas R. Article Macromolecular Bioscience (2013)
Tuning of Cell-Biomaterial Anchorage for Tissue Regeneration Daz-Cuenca, Arnzazu; Boccaccini, Aldo R. Article Advanced Materials (2013)
Cell adhesion and proliferation on RGD-modified recombinant spider silk proteins Wohlrab, Stefanie; Mller, Susanne; Schmidt, Andreas; Neubauer, Stefanie; Kessler, Horst; Scheibel, Thomas Article Biomaterials (2012)
Interactions of cells with silk surfaces Scheibel, Thomas Article Journal of Materials Chemistry (2012)
Interactions of Fibroblasts with Different Morphologies Made of an Engineered Spider Silk Protein Lang, Gregor; Mauerer, Carolin; Wickinghoff, Jasmin; Weber, Michael; Geimer, Stefan; Scheibel, Thomas Article Advanced Engineering Materials (2012)
Tuning liver stiffness against tumours: An in vitro study using entrapped cells in tumour-like microcapsules Fritsch, Anatol; Heidebrecht, Felicia; Daz-Cuenca, Arnzazu; Nowicki, Marcin; Bader, Augustinus; Ks, Josef Article JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2012)
Determination of pore size distribution at the cell-hydrogel interface Dietrich-Braumann, Ulf; Daz-Cuenca, Arnzazu; Nowicki, Marcin; Bader, Augustinus Article JOURNAL OF NANOBIOTECHNOLOGY (2011)
Determination of the decay rate constant for hepatocytes immobilized in alginate microcapsules Daz-Cuenca, Arnzazu; Bader, Augustinus Article Journal of Microencapsulation (2010)
Silk-based materials for biomedical applications LealEgaa, Aldo; Scheibel, Thomas Article Biotechnol Appl Biochem (2010)
A simple non-destructive method for the fixation and immunostaining of cultured cells encapsulated in alginate Leal-Egana, Aldo; Heinrich, J.Michael; Smith, MarkD.; Nowicki, Marcin; Bader, Augustinus Article Biotechnology and Applied Biochemistry (2006)


Re-engineering Artificial Neoplastic Milieus: Taking Lessons from Mechano- and Topobiology Leal-Egana, Aldo; Balland, Martial; Boccaccini, Aldo R. Review ISI TRENDS IN BIOTECHNOLOGY (2020)

Aldo Leal

Group Leader

IMSEAM

Heidelberg University

Heidelberg, Alemania

Miguel Fuentes

Postdoctoral researcher

Universidad de Valparaíso

Valparaíso, Chile

Aldo Nicolás Leal Egaña

Líneas de Investigación

Educación

Biotechnology, Biomaterials, Tissue Engineering, Leipzig University. Alemania, 2009

Biochemical Engineering, Pontificia Universidad Católica de Valparaíso. Chile, 2002

Biochemist, Universidad de Chile. Chile, 2001

Experiencia Académica

Group Leader Full Time

Experiencia Profesional

PhD student

Pre-doctoral researcher

Post-doctoral researcher

Guest researcher

Post-doctoral researcher

Research associate

Group Leader Full Time

Article (28)

Review (1)