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RODRIGO CARLOS DIAZ ESPINOZA

Profesor Asociado

Universidad de Santiago de Chile

Santiago, Chile

Design, development and characterization of catalytic peptide amyloid assemblies for diverse applications (bio-nanotechnology, disease and prebiotic chemistry)

Ingeniero en Biotecnologia Molecular, UNIVERSIDAD DE CHILE. Chile, 2005
Protein Aggregation, UNIVERSITY OF TEXAS MEDICAL BRANCH AT GALVESTON. Estados Unidos, 2011

Postdoctoral Researcher Full Time

UNIVERSITY OF TEXAS MEDICAL SCHOOL AT HOUSTON

HOUSTON, Estados Unidos

2011 - 2014
Postdoctoral researcher Full Time

UNIVERSIDAD DE CHILE

Ciencias

Santiago, Chile

2014 - 2016

Undergraduate Research Assistant

Universidad de Chile

Chile

2002 - 2005
Graduate Research Assistant

The University of Texas Medical Branch

Estados Unidos

2005 - 2011
Postdoctoral Researcher Full Time

The University of Texas Health Science Center

Houston, Estados Unidos

2011 - 2014
Profesor Asistente Full Time

Universidad de Santiago de Chile

Santiago, Chile

2017 - 2022
Investigador Postdoctoral Full Time

Universidad de Chile

Santiago, Chile

2014 - 2017
Profesor Asociado Full Time

Universidad de Santiago de Chile

Santiago, Chile

2022 - A la fecha


IGF2-Reprogrammed Macrophages Ameliorate the Inflammatory Response and Protect Against the Neuroinflammatory Process in Parkinson's Disease Models Grunenwald, Felipe; Huerta, Tomas J.; Sepulveda, Denisse; Jerez, Carolina; Urbina, Valentina; Carrera, Barbara; Diaz-Espinoza, Rodrigo; Nova Esteban; Pacheco, Rodrigo; Martin-Montanez, Elisa; et al. Article ISI AGING CELL (2025)
Peripheral administration of blood from tau transgenic animals exacerbates brain tau-associated pathology Vegas-Gomez, Laura; Pizarro, Matias; Garcia-Martin, Jesus; Arredondo-Alcala, Maria Angeles; Bustamante, Bianca; Gonzalez-Silva, Carolina; Matus, Soledad; Diaz-Espinoza, Rodrigo; Gutierrez, Antonia; Morales, Rodrigo; et al. Article ISI PLOS ONE (2025)
Editorial: Peptide assemblies in nanotechnology Article ISI FRONTIERS IN MOLECULAR BIOSCIENCES (2023)
IGF2 prevents dopaminergic neuronal loss and decreases intracellular alpha-synuclein accumulation in Parkinson's disease models Urbina, Valentina; Tirado, Daniel; Nova Esteban; Kubitscheck, Ulrich; Rodriguez-Gatica, Juan Eduardo; Toledo, Jorge; Martin-Montanez, Elisa; Garcia-Fernandez, Maria Article ISI CELL DEATH DISCOVERY (2023)
Catalytic Amyloids as Novel Synthetic Hydrolases Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Functional characterization of the ATPase-like activity displayed by a catalytic amyloid Castillo-Caceres, Claudio; Duran-Meza, Eva; Nova Esteban; Araya-Secchi, Raul; Monasterio, Octavio Article ISI BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2021)
Recent High-Resolution Structures of Amyloids Involved in Neurodegenerative Diseases Article WOS FRONTIERS IN AGING NEUROSCIENCE (2021)
Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo Article ISI SCOPUS MOLECULAR PSYCHIATRY (2018)
Development of a novel catalytic amyloid displaying a metal-dependent ATPase-like activity Monasterio, Octavio; Nova Esteban Article ISI https://doi.org/10.1016/j.bbrc.2016.12.011 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)
Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding Article ISI https://doi.org/10.1038/mp.2016.230 MOLECULAR PSYCHIATRY (2017)
Overcoming Electrostatic Repulsions During Amyloid Assembly: Effect of pH and Interaction With Divalent Metals Using Model Peptides Nova Esteban; Monasterio, Octavio Article ISI https://doi.org/10.1016/j.abb.2017.03.003 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2017)
Prion-like characteristics of the bacterial protein Microcin E492 Article ISI doi: 10.1038/srep45720 (2017) SCIENTIFIC REPORTS (2017)
Strain-dependent profile of misfolded prion protein aggregates Morales, Rodrigo Article ISI doi: 10.1038/srep20526 (2016) SCIENTIFIC REPORTS (2016)
The extent of protease resistance of misfolded prion protein is highly dependent on the salt concentration. Concha-Marambio, Luis; Diaz-Espinoza, Rodrigo; Soto, Claudio Article The Journal of biological chemistry (2014)
High-resolution structure of infectious prion protein: the final frontier. Diaz-Espinoza, Rodrigo; Soto, Claudio Article Nature structural & molecular biology (2012)
Kosmotropic anions promote conversion of recombinant prion protein into a PrPSc-like misfolded form. Diaz-Espinoza, Rodrigo; Mukherjee, Abhisek; Soto, Claudio Article PloS one (2012)
Protein misfolding cyclic amplification of infectious prions. Morales, Rodrigo; Duran-Aniotz, Claudia; Diaz-Espinoza, Rodrigo; Camacho, Manuel V; Soto, Claudio Article Nature protocols (2012)
Generation of prions in vitro and the protein-only hypothesis. Diaz-Espinoza R, Soto C. Article Prion (2010)
Molecular cross talk between misfolded proteins in animal models of Alzheimer's and prion diseases. Morales, Rodrigo; Estrada, Lisbell D; Diaz-Espinoza, Rodrigo; Morales-Scheihing, Diego; Jara, Maria C; Castilla, Joaquin; Soto, Claudio Article The Journal of neuroscience : the official journal of the Society for Neuroscience (2010)
Transport of prion protein across the blood-brain barrier. Banks, W A; Robinson, Sandra M; Diaz-Espinoza, R; Urayama, A; Soto, C Article Experimental neurology (2009)
Domain folding and flexibility of Escherichia coli FtsZ determined by tryptophan site-directed mutagenesis. Díaz-Espinoza, Rodrigo; Garcés, Andrea P; Arbildua, José J; Montecinos, Felipe; Brunet, Juan E; Lagos, Rosalba; Monasterio, Octavio Article Protein science : a publication of the Protein Society (2007)


Catalytic amyloids for nucleotide hydrolysis. Carrillo D., Duran-Meza E., Castillo-Caceres C., Alarcon DE., Guzman H., Diaz-Espinoza R.; ivan Korendovych BookSection (2024)
Design and Testing of Synthetic Catalytic Amyloids Based on the Active Site of Enzymes Arluison, Veronique BookSection (2022)


An Experimental Study of the Involvement of Catalytic Amyloids on Prebiotic Chemistry Proyecto (2021)
Fortalecimiento de la docencia de pregrado en Bioquímica, e implementación de una nueva línea de investigación en Biología Estructural y Computacional orientadas a los Doctorados de Neurociencias y Biotecnología CONICYT (PAI) (PAI79160143) Proyecto 2017-2020 Inv. Principal
AN EXPLORATORY APPROACH TO STUDY THE CATALYTIC PROPERTIES OF AMYLOIDS AND THEIR BIOLOGICAL IMPLICATIONS FONDECYT (11160554) Proyecto 2016-2019 Inv. Responsable
EMERGENCE OF NUCLEOTIDYLTRANSFERASE ACTIVITY FROM SELF-ASSEMBLED PEPTIDE AMYLOIDS FONDECYT (3150054) Proyecto 2014-2016 Inv. Responsable
ESTABILIDAD Y MECANISMO DE PLEGAMIENTO DE FTSZ Y TUBULINA, Y SU RELACION CON LA ACTIVIDAD GTPASICA EN EL CONTROL DE LA POLIMERIZACION FONDECYT (1010848) Proyecto 2001-2005 Tesista