1a66cfa4-34ed-4a12-8963-53b5a3d41907_4_5005_c.jpeg_thumb90

Leyla Morelia Alegria Vargas

Profesor Asistente

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Epidemiology, Sleep in critically ill patients, Post-Intensive Care Syndrome, Follow-up od survivors , Patient and Public Involvement in Research (PPI)

Educación

  •  Epidemiología, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2017
  •  Enfermera Matrona, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2005
  •  Mención medicina intensiva, Erasmus MC. Holanda, 2025

Experiencia Académica

  •   Enfermera de Investigación Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2012 - 2023

  •   Profesor Asistente Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago , Chile

    2023 - A la fecha

  •   Profesor Asistente Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago , Chile

    2023 - A la fecha

Experiencia Profesional

  •   Enfermera Clínica Unidad de Cuidados Intensivos Full Time

    Hospital Clínico de la Universidad Católica de Chile

    Chile

    2005 - 2012

  •   Comité Editorial Other

    Revista Chilena de Medicina Intensiva

    Santiago, Chile

    2015 - 2023

  •   Miembro directorio ejecutivo Part Time

    Sociedad Chilena de Medicina Intensiva

    Santiago, Chile

    2024 - A la fecha

Formación de Capital Humano


Tutora de tesis de Magíster de Epidemiología, Facultad de Medicina, Pontificia Universidad Católica de Chile
Co-Tutora de tesis de Magíster en Psicología de la Salud, Escuela de Psicología, Pontificia Universidad Católica de Chile
Tutora de 1 tesis de Magister de Enfermería, Escuela de Enfermería, Pontificia Universidad Católica de Chile
Tutora de 2 tesis de Magister de Investigación en Ciencias de la Salud, Facultad de Medicina, Pontificia Universidad Católica de Chile



 

Article (28)

Effect of decreasing respiratory rate on the mechanical power of ventilation and lung injury biomarkers: a randomized cross-over clinical study in COVID-19 ARDS patients

Damiani, LF; Basoalto, R; Oviedo, V; Alegría, L.; Soto, D; Bachmann, MC; Jalil, Y; Santis, C; Carpio, D; Ulloa, R; et al.

Article ISI
INTENSIVE CARE MEDICINE EXPERIMENTAL  (2025)

Nonpharmacological interventions to promote sleep in the adult critical patients unit: A scoping review

Carrera,Maria P.; Brockmann,Pablo; Repetto,Paula; Douglas Leonard; Cádiz,Rodrigo; Paredes,Fabio; Rojas,Idalid; Moya,Ana; Oviedo,Vanessa; García,Patricio; et al.

Article ISI
AUSTRALIAN CRITICAL CARE  (2025)

Spiritual care for prevention of psychological disorders in critically ill patients: study protocol of a feasibility randomised controlled pilot trial

Repetto, P; Ruiz, C; Rojas, V; Olivares, P; Bakker, J; Alegría, L.

Article ISI
BMJ OPEN  (2025)

Capillary refill time response to a fluid challenge or a vasopressor test: an observational, proof-of-concept study

Hernandez, Glenn; Castro, Ricardo; Kraemer, Alicia Elzo; Sarzosa, Nicolas; Saéz, Claudia; Ait-Oufella, Hafid

Article ISI
ANNALS OF INTENSIVE CARE  (2024)

Customized normothermic machine perfusion decreases ischemia-reperfusion injury compared with static cold storage in a porcine model of liver transplantation

Jose Zenteno, Maria; San Martin, Sebastian

Article ISI
ARTIFICIAL ORGANS  (2023)

Improve sleep in critically ill patients: Study protocol for a randomized controlled trial for a multi-component intervention of environment control in the ICU

Repetto,Paula; Leonard, Douglas; Cadiz, Rodrigo; Rojas, Idalid; Moya, Ana

Article ISI
PLOS ONE  (2023)

Physiological effects of high-flow nasal cannula oxygen therapy after extubation: a randomized crossover study

Cornejo, Rodrigo; Thille, Arnaud W.

Article ISI
ANNALS OF INTENSIVE CARE  (2023)

Continuous prolonged prone positioning in COVID-19-related ARDS: a multicenter cohort study from Chile

Cornejo, Rodrigo A.; Montoya, Jorge; Graf, Jeronimo; Baghetti, Romyna; Irarrazaval, Anita; Leighton, Sofia; Tomicic, Vinko; Morales, Daniel; Ruiz, Carolina; Navarrete, Pablo; et al.

Article ISI
ANNALS OF INTENSIVE CARE  (2022)

Exploring the relationship between capillary refill time, skin blood flow and microcirculatory reactivity during early resuscitation of patients with septic shock: a pilot study

Hernandez, Glenn; Gonzalez, Cecilia; Ulloa, Rodrigo; Castro, Ricardo; Guzman, Camila; Adolfo Ospina-Tascon, Gustavo

Article ISI
JOURNAL OF CLINICAL MONITORING AND COMPUTING  (2022)

Reduction of Respiratory Rate in COVID-19-Associated ARDS

Felipe Damiani, L.; Soto, Dagoberto; Consuelo Bachmann, M.; Retamal, Jaime; Bruhn, Alejandro; Bugedo, Guillermo

Article ISI
RESPIRATORY CARE  (2022)

Effect of positive end-expiratory pressure on lung injury and haemodynamics during experimental acute respiratory distress syndrome treated with extracorporeal membrane oxygenation and near-apnoeic ventilation

Cruces, Pablo; Soto, Dagoberto; Valenzuela, Emilio D.; Retamal, Jaime; Cornejo, Rodrigo; Bugedo, Guillermo; Bruhn, Alejandro

Article ISI
BRITISH JOURNAL OF ANAESTHESIA  (2021)

Implementation and design of customized ex vivo machine perfusion. Analysis of its first results

Morales, Emilio; Soto, Dagoberto; Josefina Zenteno, Maria; Rebolledo, Rolando A.

Article ISI
ARTIFICIAL ORGANS  (2021)

Effects of capillary refill time-vs. lactate-targeted fluid resuscitation on regional, microcirculatory and hypoxia-related perfusion parameters in septic shock: a randomized controlled trial

Castro, Ricardo; Astudillo, Brusela; Cid, Maria Alicia; Hernandez, Glenn

Article ISI
ANNALS OF INTENSIVE CARE  (2020)

Hypoxia-related parameters during septic shock resuscitation: Pathophysiological determinants and potential clinical implications

Pavez, Nicolas; Ferri, Giorgio; Daniel Valenzuela, Emilio; Pairumani, Ronald; Santis, Cesar; Oviedo, Vanessa; Soto, Dagoberto; Hernandez, Glenn; Castro, Ricardo

Article ISI
ANNALS OF TRANSLATIONAL MEDICINE  (2020)

Low Spontaneous Breathing Effort during Extracorporeal Membrane Oxygenation in a Porcine Model of Severe Acute Respiratory Distress Syndrome

Oviedo, Vanesa; Garcia, Alinee; Bachmann, Maria Consuelo; Basoalto, Roque; Soto, Dagoberto; Cruces, Pablo; Retamal, Jaime; Cornejo, Rodrigo; Bugedo, Guillermo; Bruhn, Alejandro

Article ISI
ANESTHESIOLOGY  (2020)

Systematic assessment of fluid responsiveness during early septic shock resuscitation: secondary analysis of the ANDROMEDA-SHOCK trial

Ospina-Tascón G.A.; Pairumani R.; Holger P.; Cook D.; Kavanagh B.P.; Dellinger P.; Rietdijk W.

Article ISI SCOPUS
CRITICAL CARE  (2020)

Early rise in central venous pressure during a spontaneous breathing trial: A promising test to identify patients at high risk of weaning failure?

Dubo, Sebastian; Valenzuela, Emilio Daniel; Jibaja, Manuel; Berrutti, Dolores; Labra, Christian; Lagos, Rossana; García, María Fernanda; Ramírez, Vanessa; Tobar, Milton; Picoita, Fabricio; et al.

Article ISI SCOPUS
PLOS ONE  (2019)

Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock=> The ANDROMEDA-SHOCK Randomized Clinical Trial.

Hernández, Glenn; Ospina-Tascón, Gustavo A; Damiani, Lucas Petri; Estenssoro, Elisa; Dubin, Arnaldo; Hurtado, Javier; Friedman, Gilberto; Castro, Ricardo; Alegría, Leyla; Teboul, Jean-Louis; Cecconi, Maurizio; Ferri, Giorgio; Jibaja, Manuel; Pairumani, Ronald; Fernández, Paula; Barahona, Diego; Granda-Luna, Vladimir; Cavalcanti, Alexandre Biasi; Bakker, Jan; Hernández, Glenn; Ospina-Tascón, Gustavo; Petri Damiani, Lucas; Estenssoro, Elisa; Dubin, Arnaldo; Hurtado, Javier; Friedman, Gilberto; Castro, Ricardo; Alegría, Leyla; Teboul, Jean-Louis; Cecconi, Maurizio; Cecconi, Maurizio; Ferri, Giorgio; Jibaja, Manuel; Pairumani, Ronald; Fernández, Paula; Barahona, Diego; Cavalcanti, Alexandre Biasi; Bakker, Jan; Hernández, Glenn; Alegría, Leyla; Ferri, Giorgio; Rodriguez, Nicolás; Holger, Patricia; Soto, Natalia; Pozo, Mario; Bakker, Jan; Cook, Deborah; Vincent, Jean-Louis; Rhodes, Andrew; Kavanagh, Bryan P; Dellinger, Phil; Rietdijk, Wim; Carpio, David; Pavéz, Nicolás; Henriquez, Elizabeth; Bravo, Sebastian

Article
JAMA  (2019)

Near-Apneic Ventilation Decreases Lung Injury and Fibroproliferation in an Acute Respiratory Distress Syndrome Model with Extracorporeal Membrane Oxygenation.

Araos, Joaquin; Alegria, Leyla; Garcia, Patricio; Cruces, Pablo; Soto, Dagoberto; Erranz, Benjamín; Amthauer, Macarena; Salomon, Tatiana; Medina, Tania; Rodriguez, Felipe; Ayala, Pedro; Borzone, Gisella R; Meneses, Manuel; Damiani, Felipe; Retamal, Jaime; Cornejo, Rodrigo; Bugedo, Guillermo; Bruhn, Alejandro

Article
American journal of respiratory and critical care medicine  (2019)

Early goal-directed therapy using a physiological holistic view=> the ANDROMEDA-SHOCK-a randomized controlled trial.

Hernández, Glenn; Cavalcanti, Alexandre Biasi; Ospina-Tascón, Gustavo; Zampieri, Fernando Godinho; Dubin, Arnaldo; Hurtado, F Javier; Friedman, Gilberto; Castro, Ricardo; Alegría, Leyla; Cecconi, Maurizio; Teboul, Jean-Louis; Bakker, Jan

Article
Annals of intensive care  (2018)

Evaluation of Meropenem Pharmacokinetics in an Experimental Acute Respiratory Distress Syndrome (ARDS) Model during Extracorporeal Membrane Oxygenation (ECMO) by Using a PenP -Lactamase Biosensor.

Andresen, Max; Araos, Joaquin; Wong, Kwok-Yin; Leung, Yun-Chung; So, Lok-Yan; Wong, Wai-Ting; Cabrera, Salvador; Silva, Camila; Alegria, Leyla; Bruhn, Alejandro; Soto, Dagoberto

Article
Sensors (Basel, Switzerland)  (2018)

Statistical analysis plan for early goal-directed therapy using a physiological holistic view - The andromeda-shock: A randomized controlled trial

Ospina-Tascón G.; Damiani L.P.; Alegría L.

Article ISI SCOPUS
Revista Brasileira de Terapia Intensiva  (2018)

The practice of intensive care in Latin America: a survey of academic intensivists

Nin, N; Alegría, L.; Estenssoro, E; Murias, G; Friedman, G; Marin, MD; Machado, FR; Cavalcanti, AB; Dubin, A; Cecconi, M

Article ISI SCOPUS
CRITICAL CARE  (2018)

A hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study

Alegría Leyla; Bakker, Jan; Teboul Louis; Ospina-Tascon, Gustavo

Article ISI SCOPUS
ANNALS OF INTENSIVE CARE  (2017)

Effects of dexmedetomidine and esmolol on systemic hemodynamics and exogenous lactate clearance in early experimental septic shock.

Hernández, Glenn; Tapia, Pablo; Alegría, Leyla; Soto, Dagoberto; Luengo, Cecilia; Gomez, Jussara; Jarufe, Nicolas; Achurra, Pablo; Rebolledo, Rolando; Bruhn, Alejandro; Castro, Ricardo; Kattan, Eduardo; Ospina-Tascón, Gustavo; Bakker, Jan

Article
Critical care (London, England)  (2016)

Extracorporeal membrane oxygenation improves survival in a novel 24-hour pig model of severe acute respiratory distress syndrome

Araos, J; Alegría, L.; Garcia, P.; Damiani, F; Tapia, P; Soto, D; Salomon T.; Rodriguez,F; Amthauer M.; Erranz, B; et al.

Article SCOPUS
American Journal of Translational Research  (2016)

Method Based on the beta-Lactamase PenPC Fluorescent Labeled for beta-Lactam Antibiotic Quantification in Human Plasma

Andresen M.; Wong, KY; Leung, YC; Wong, WT; Chan, PH; Andresen-Vasquez, M; Alegría, L.; Silva, C; Tapia, P; Downey P.; et al.

Article ISI SCOPUS
BIOMED RESEARCH INTERNATIONAL  (2016)

Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion

Tapia, P; Soto, D; Bruhn, A; Alegría, L.; Jarufe, N.; Luengo C.; Kattan, E; Regueira T.; Meissner, A; Menchaca, R; et al.

Article ISI SCOPUS
Critical Care  (2015)

Proyecto (8)

Effect of Continuous Prolonged Prone Position versus Intermittent Daily Prone Position on Mortality in ARDS Patients: A Multicenter Randomized Controlled Trial

Alejandro Bruhn

Proyecto
 (2024)

Post ICU Syndrome: Exploring the Role of Social Determinants on Trajectories and Outcomes.

Paula Repetto Lisboa

Proyecto
 (2024)

Sistema de iluminación dinámico de bajo costo para mejorar el sueño y ritmo circadiano en pacientes críticos.

Leyla Alegría

Proyecto
 (2023)

Impacto de una estrategia de comunicación precoz e integral en la prevención de síntomas depresivos en pacientes con Covid-19 grave, sus familiares y el personal de salud

Eduardo Tobar A.; Paula Repetto L.; Manuel Ortiz; María Pilar Celis

Proyecto ClinicalTrials NCT05035563
 (2021)

Capillary refill time response to a rapid fluid challenge in septic shock patients: pathophysiological determinants, and relation to changes in systemic, regional and microcirculatory blood flow.



Proyecto
 (2020)

Impact of the use a multifaceted intervention of environment control in the ICU to optimize quantity and quality of sleep in critically ill patients.



Proyecto
 (2020)

“Secuelas psicológicas en pacientes críticos a los tres meses del alta de la Unidad de Cuidados Intensivos”

Pontificia Universidad Católica de Chile (180904004)

Proyecto
2019-2020
Tesista

PERIPHERAL PERFUSION VERSUS LACTATE-TARGETED FLUID RESUSCITATION IN SEPTIC SHOCK=> A RANDOMIZED CONTROLLED STUDY

FONDECYT (1170043)

Proyecto
2017-2020
Coinvestigador(a)

1
Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Patricio Downey

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE DEPARTAMENTO DE NEFROLOGIA

SANTIAGO, Chile

1
Pablo Cruces

MEDICO RESIDENTE

PEDIATRIA

HOSPITAL EL CARMEN DE MAIPU

SANTIAGO, Chile

2
Rodrigo Cadiz

Professor

Electrical Engineering

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile, Chile

8
Alejandro Bruhn

Profesor Titular. Director de Investigación y Postgrado, Facultad de Medicina

Departamento de Medicina Intensiva

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Nicolas Jarufe

Chief Digestive Surgery

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Pablo Tapia

Jefe Técnico Unidad de Paciente Crítico (UPC)

Unidad Paciente Critico (UPC)

Hospital Clinico Metropolitano La Florida

Santiago, Chile

1
Benjamín Erranz

Investigador-Docente

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

1
Max Andresen

profesor asociado categoria ordinaria

medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

5
Jaime Retamal

Profesor Asociado

Medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Dagoberto Soto

Investigador

Universidad Católica de Chile

santiago, Chile

4
Guillermo Bugedo

Staff Medicina Intensiva

Medicina Intensiva

Pontifica Universidad Catolica de Chile

Santiago, Chile

5
María Vera

Académico

Medicina Intensiva

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
David Carpio

Residente

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago , Chile

29
Leyla Alegria

Profesor Asistente

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Alejandro Bruhn

Jefe Unidad de Paciente Critico

Hospital Clinico de la Universidad Catolica

Santiago, Chile

3
Eduardo Kattan

Profesor Asistente

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Sebastián Dubo

Profesor Asociado

Kinesiología

Universidad de Concepción

Concpeción, Chile

1
Christian Labra

kinesiólogo

kinesiología

Hospital red de salud UC

santiago, Chile

1
Pablo Guzmán

Pathologist

Hospital Regional Dr. Hernán Henríquez Araven

Temuco, Chile

1
Jorge Dreyse

Medico Broncopulmonar

Centro Enfermedades Respiratorias y Cirugia de Tórax

Clinica Las Condes

Las Condes, Chile

1
Carolina Henriquez

Enfermera coodinadora

Infectologia Pediátrica / Medicina Interna

Pontificia Universidad Católica de Chile

Santiago, Chile

5
Vanessa Oviedo

ENFERMERA DE INVESTIGACIÓN

DEPARTAMENTO DE MEDICINA INTENSIVA

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
Sebastian Bravo

Profesor Asistente

Medicina Intenciva

Pontificia Universidad Católica de Chile

santiago, Chile

1
Tania Medina

Enfermera clínica

Hospital El Carmen

Santiago, Chile

8
Emilio Valenzuela

3
Luis Damiani

Profesor Asistente

Kinesiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Macarena Amthauer

Enfermera de Investigación

Medicina Intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Rolando Rebolledo

Cirujano

Servicio de Cirugía

Hospital Dr. Sótero del Río

Santiago, Chile

4
Cesar Santis

Médico

Unidad Cuidados Intensivos

Hospital Barros Luco

Santiago, Chile

2
Yorschua Jalil

Coordinador area de cuidados cardiorespiratorios

Kinesiología

Pontificia Universidad Católica de Chile

Santiago, Chile

4
ROQUE BASOALTO

Kinesiólogo

Medicina Física y Rehabilitación

Hospital Clínico UC-CHRISTUS

santiago, Chile

1
douglas leonard

FUNDADOR

DISEÑO DE ILUMINACIÓN

DLLDSPA

SANTIAGO, Chile