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Valeria Razmilic

Investigadora postdoctoral

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Biotecnología microbiana. Ingeniería genética y metabólica para la optimización de producción de metabolitos. Bioprospección de Actinobacterias. Minería de genomas y desarrollo de modelos metabólicos.

Educación

  •  Doctorado en Ciencias de la Ingeniería mención Ingeniería Química y Biotecnología, UNIVERSIDAD DE CHILE. Chile, 2017
  •  Bioingeniero, UNIVERSIDAD DE CONCEPCION. Chile, 2010

Experiencia Académica

  •   Ayudante en Biología Celular Other

    UNIVERSIDAD DE CONCEPCION

    Ciencias Biológicas

    Concepción, Chile

    2008 - 2008

  •   Ayudante en Sanidad Vegetal Other

    UNIVERSIDAD DE CONCEPCION

    Ciencias Forestales

    Concepción, Chile

    2009 - 2009

  •   Ayudante en Curso de Proyecto Other

    UNIVERSIDAD DE CHILE

    Ciencias Físicas y Matemáticas

    Santiago, Chile

    2012 - 2012

  •   Ayudante en laboratorio de técnicas de Biología Moderna Other

    UNIVERSIDAD DE CHILE

    Ciencias Físicas y Matemáticas

    Santiago, Chile

    2012 - 2012

  •   Ayudante de Taller de Proyecto Part Time

    UNIVERSIDAD DE CHILE

    Ciencias Físicas y Matemáticas

    Santiago, Chile

    2015 - 2015

  •   Profesor auxiliar Ingeniería metabolica y fermentación Part Time

    UNIVERSIDAD DE CHILE

    Ciencias Físicas y Matemáticas

    Santiago, Chile

    2021 - A la fecha

  •   Profesor auxiliar Bioinformática Part Time

    UNIVERSIDAD DE CHILE

    Ciencias Físicas y Matemáticas

    Santiago, Chile

    2020 - 2022

Experiencia Profesional

  •   Asistente de investigación Full Time

    Universidad de Concepción

    Concepción, Chile

    2010 - 2011

  •   Investigadora post-doctoral Full Time

    Universidad de Chile

    Santiago, Chile

    2017 - A la fecha

Difusión y Transferencia


8 - 10 September, 2025: Oral presentation: "Unveiling the biotechnological potential of Actinobacteria isolated from Atacama Desert soils" in Workshop Exploring Chilean Microbial Diversity, Universidad Técnica Federico Santa María, Valparaíso, Chile.

5 - 10 November, 2023: Poster presentation: Novel Lasso Peptides Produced By Actinobacteria from the Atacama Desert. AICHE annual meeting, Orlando, USA.

17 - 21 September, 2023: Presentation: Production of lasso peptides from actinobacteria isolated from the Atacama Desert as a novel source of bioactive
compounds. 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology (14ECCE/7ECAB), Berlin, Germany.

30 October - 3 November, 2022: Presentation: Microbial engineering of new Streptomyces sp. from extreme environments for novel antiobitics, anticancer and antifungal drugs. Engineering Conference International (ECI), Santa Fe, New Mexico, USA.

15 - 19 September, 2019: Presentation "Micromonospora sp. STR1S-6 and STR1-7 as a source of novel bioactive compounds" in The 5th European Congress of Applied Biotechnology (ECAB 5), Florence, Italy.

29 – 31 July, 2019: Oral Presentation “Strains from the Atacama Desert as producers of specialised metabolites” at X Workshop CEBIB “Metabolic Engineering, Bioinformatics and Genomics for Biotechnological Application”, Hotel Sheraton San Cristobal, Santiago, Chile.

03 – 05 December, 2018: Oral Presentation “Micromonosporas from the Atacama Desert as producers of specialised metabolites” at IX Workshop CEBIB “Bioinformatics, Genomics, and Bioengineering in Biotechnological Applications”, Hotel Dreams, Temuco, Chile.

9 - 11 September, 2018: Presentation "Metabolic Engineering of new Streptomyces sp. From Extreme Environments for Novel Antibiotics and Anticancer Drugs". European Society of Biochemical engineering sciences (ESBES), Lisbon, Portugal.

29 November – 01 December, 2017: Oral Presentation “Isolation of Micromonosporas and other Actinobacteria strains from the Atacama Desert” at VII Workshop CEBIB “Genomics, Metabolic Engineering and Bioinformatics in Biotechnological Applications”, Hotel Antofagasta, Antofagasta, Chile.

30 November - 02 December, 2016: Oral Presentation “Genomic potential of Streptomyces leeuwenhoekii C34 for producing specialised metabolites” at V Workshop CEBIB “Genomics, Metabolic Engineering and Bioinformatics in Biotechnological Applications”, Hotel Radisson, Puerto Varas, Chile.

04-06 July, 2016: Oral Presentation “Prediction of modifications that enhance the production of specialized metabolites in Streptomyces leeuwenhoekii C34” at IV Workshop CEBIB “Fostering Collaborations in Biotechnology, Bioengineering and Bioinformatics”, Hotel Radisson, Santiago, Chile.

02-04 December, 2015: Oral Presentation “Genome scale model of Streptomyces leeuwenhoekii C34: toward improving specialised metabolites” at III Workshop CEBIB “Genomics, Metabolic Engineering and Bioinformatics in Biotechnological Applications”, Santa Cruz, Chile.

08-10 July, 2015: Poster Presentation “Development of a genome-scale model of Streptomyces leeuwenhoekii” at II Workshop CEBIB "Bioinformatics and Mathematical Modelling in Biotechnological, Molecular Genetics and Ecophysiological Applications", Hotel Manquehue, Santiago.

26-28 November, 2014: Oral Presentation “Streptomyces leeuwenhoekii: searching for specialised metabolites” at I Workshop Centre of biotechnology and Bioengineering CEBIB, Marbella, Chile. 13-21 September, 2014: Attended Summer School on “Microbial Specialised Metabolites: Origins and Applications”, Dubrovnik, Croatia.

28 August, 2014: Oral Presentation “Genome mining of Streptomyces leeuwenhoekii C34, an isolate from the Atacama Desert, for discovery of novel natural products and development of a genome scale model”. Antofagasta, Chile.

14-17 April, 2014: Attended the Society of General Microbiology annual conference in Liverpool, UK.

18 November, 2013: Attended the Young Microbiologists Symposium, John Innes Centre, Norwich, UK.

16-18 October, 2013: Attended the Annual Science Meeting, John Innes Centre, Norwich, UK.

30-31 October, 2012: Oral Presentation in Workshop “A Microbiological Overview of the Atacama Desert: Novel Natural Products of Extreme Environments”, University of Chile, Santiago, Chile.

5-7 December, 2011: Oral Presentation “Modelo a escala genómica de Acidithiobacillus ferrooxidans ATCC 23270” at V Workshop of the Cell dynamics and Biotechnology institute (ICDB), Resort Marbella, Chile.


Premios y Distinciones

  •   Assistance to Events and Short Courses for Doctorate Students Grant

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2014

    Grant awarded by the National commission of science and technology (CONICYT) to finance the assistance to the summer school “Microbial Specialised Metabolites: Origins and Applications” at Dubrovnik, Croatia.

  •   Doctoral Internship Abroad Grant

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2012

    Grant awarded by CONICYT for doing a nine months internship at John Innes Centre, University of East Anglia, UK.

  •   National Doctorate fellowship

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2011

    Fellowship granted by CONICYT to finance and support my Ph.D. studies at University of Chile, Santiago, Chile.

  •   Best engineering student, 2009 promotion of Bioengineer major.

    UNIVERSIDAD DE CONCEPCION

    Chile, 2009

    Recognition obtained as best engineering student of the 2009 promotion of the major Bioengineering.


 

Article (14)

Metabolic Engineering of Streptomyces leeuwenhoekii C34T to Increase Chaxamycin Production Based on the iVR1007 Genome-Scale Model
Predictions to Increase Lasso Peptide Production in the Heterologous Host Streptomyces coelicolor M1152
Recombinant Expression and Characterization of a Novel Type I Baeyer-Villiger Monooxygenase from a Streptomyces Strain Isolated from the Rhizosphere of the Atacama Desert Lupinus oreophilus
Micromonospora parastrephiae sp. nov. and Micromonospora tarensis sp. nov., isolated from the rhizosphere of a Parastrephia quadrangularis plant growing in the Salar de Tara region of the Central Andes in Chile
Mutactimycin AP, a New Mutactimycin Isolated from an Actinobacteria from the Atacama Desert
Heterologous Expression of a Cryptic Gene Cluster from Streptomyces leeuwenhoekii C34(T) Yields a Novel Lasso Peptide, Leepeptin
Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil
Analysis of metabolic networks of Streptomyces leeuwenhoekii C34 by means of a genome scale model: Prediction of modifications that enhance the production of specialized metabolites
Hunting for cultivable Micromonospora strains in soils of the Atacama Desert
Metabolic modelling and flux analysis of microorganisms from the Atacama Desert used in biotechnological processes
Acidithiobacillus ferrooxidans's comprehensive model driven analysis of the electron transfer metabolism and synthetic strain design for biomining applications
Identification and Heterologous Expression of the Chaxamycin Biosynthesis Gene Cluster from Streptomyces leeuwenhoekii
The Streptomyces leeuwenhoekii genome: de novo sequencing and assembly in single contigs of the chromosome, circular plasmid pSLE1 and linear plasmid pSLE2
Genome based metabolic flux analysis of Ethanoligenens harbinense for enhanced hydrogen production

Proyecto (2)

Production of lasso peptides from actinobacteria isolated from the Atacama Desert as a novel source of bioactive compounds
Bioprospecting the Atacama Desert: the discovery and enhancement of novel therapeutic drugs from actinomycetes

Review (1)

The gifted actinomycete Streptomyces leeuwenhoekii
1
Ziomara Gerdtzen

Profesora Asociada

Departamento de Ingeniería Química, Biotecnología y Materiales

Universidad de Chile

Santiago, Chile

7
Barbara Andrews

FULL PROFESSOR

CHEMICAL ENGINEERING AND BIOTECHNOLOGY

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Juan Asenjo

Professor

CHEMICAL AND BIOTECHNOLOGY ENGINEERING

University of Chile

SANTIAGO, Chile

1
Daniela Vaisman

Gerente General

Botanitec

San Antonio, Chile

8
Jean Castro

Curador

Banco de Recursos Genéticos Microbiano

Instituto de Investigaciones Agropecuarias

Chillán, Chile

17
Valeria Razmilic

Investigadora postdoctoral

Centro de Biotecnología y Bioingeniería

Universidad de Chile

Santiago, Chile

1
Francisca Marchant

Research assistant

Universidad de Chile

Santiago, Chile

1
FRANCESCA MERCADO

Gerente de Calidad y Sostenibilidad

Operaciones

Wurth Group

Santiago, Chile

1
Sebastián Rodríguez

Investigador

departamento de ingeniería química, biotecnología y materiales

Universidad de Chile

Santiago, Chile