Man

Marcelo Andrés González Ortiz

Profesor Asociado

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

Líneas de Investigación


Mecanismos moleculares y celulares de regulación de la fisiología vascular placentaria humana, en condiciones saludables y de patologías, principalmente diabetes gestacional, preeclampsia y obesidad.

Educación

  •  Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2004
  •  Ciencias Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
  •  Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CONCEPCION

    Medicina

    CONCEPCION, Chile

    2019 - A la fecha

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CONCEPCION

    Ciencias Biológicas

    CONCEPCION, Chile

    2009 - 2019

Experiencia Profesional

  •   Profesor Asociado Full Time

    Universidad de Concepción

    Concepción, Chile

    2009 - A la fecha

Formación de Capital Humano


Supervisión de Tesis

Magister en Fisiología Humana (UdeC): Pía Ávila, Lissette Cabrera, Iván Rodríguez, Tamara Ortiz, Sebastián Dubó, Victor Durán, Enzo Barrientos, Natalia Rodríguez, Víctor Lincoñir.

Magíster en Salud Sexual y Reproductiva (UdeC): María Fernanda Castillo (co-tutor).

Licenciatura en Bioquímica (UdeC): Natalia Vallejos, Emerita Basualto, Luz Valdivia, Astrid Haensgen, Andrea Saavedra, Roberto Villalobos, Carlos Palma, Cristina Valenzuela.

Licenciatura en Bioingeniería (UdeC): Pamela Careaga, David Gallegos, Rubén Grandón

Ingeniería Química (UdeC): María Soledad Parada (co-tutor).


Premios y Distinciones

  •   Asignación Académica

    UNIVERSIDAD DE CONCEPCION

    Chile, 2019

    Asignación al mérito académico (docencia, investigación, extensión) de acuerdo a lo realizado en los últimos 3 años del periodo.


 

Article (49)

Maternal thyroid profile in first and second trimester of pregnancy is correlated with gestational diabetes mellitus through machine learning
Deletion of the adenosine A(2A)receptor increases the survival rate in a mice model of polymicrobial sepsis
High levels of maternal total tri-iodothyronine, and low levels of fetal free L-thyroxine and total tri-iodothyronine, are associated with altered deiodinase expression and activity in placenta with gestational diabetes mellitus
Improvement of endothelial function by <i>Gunnera tinctoria</i> extract with antioxidant properties
Improvement of endothelial function by Gunnera tinctoria extract with antioxidant properties
The activity of IKCa and BKCa channels contributes to insulin-mediated NO synthesis and vascular tone regulation in human umbilical vein
Pharmacological inhibition of the F-1-ATPase/P2Y(1) pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation
Pharmacological inhibition of the F1 -ATPase/P2Y1 pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation.
Role of heme oxygenase 1 and human chorionic gonadotropin in pregnancy associated diseases.
Transport of biodegradable polymeric particles loaded with grape seed extract across Caco-2 cell monolayers
Akt/mTOR role in human foetoplacental vascular insulin resistance in diseases of pregnancy
Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1.
Pro-angiogenic Role of Insulin=> From Physiology to Pathology
Cardiovascular Action of Insulin in Health and Disease: Endothelial L-Arginine Transport and Cardiac Voltage-Dependent Potassium Channels.
Insulin Induces Relaxation and Decreases Hydrogen Peroxide-Induced Vasoconstriction in Human Placental Vascular Bed in a Mechanism Mediated by Calcium-Activated Potassium Channels and L-Arginine/Nitric Oxide Pathways
Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus.
Potential benefits of physical activity during pregnancy for the reduction of gestational diabetes prevalence and oxidative stress.
Synthesis and characterization of polyhydroxybutyrate-co-hydroxyvalerate nanoparticles for encapsulation of quercetin
Biología del desarrollo vascular: Mecanismos en condiciones fisiológicas y estrés de flujo
Insulin Reverses D-Glucose-Increased Nitric Oxide and Reactive Oxygen Species Generation in Human Umbilical Vein Endothelial Cells
Insulin reverses d-glucose-increased nitric oxide and reactive oxygen species generation in human umbilical vein endothelial cells.
Lemon grass (Cymbopogon citratus (D.C) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidised low-density lipoprotein
Lemon grass (Cymbopogon citratus (D.C) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidised low-density lipoprotein.
Physiological mechanisms of vascular response induced by shear stress and effect of exercise in systemic and placental circulation.
Impaired A(2A) adenosine receptor/nitric oxide/VEGF signaling pathway in fetal endothelium during late- and early-onset preeclampsia
Impaired A2A adenosine receptor/nitric oxide/VEGF signaling pathway in fetal endothelium during late- and early-onset preeclampsia.
Supplementation with apple enriched with L-arginine may improve metabolic control and survival rate in alloxan-induced diabetic rats
Supplementation with apple enriched with L-arginine may improve metabolic control and survival rate in alloxan-induced diabetic rats.
Biosynthesis of selenium nanoparticles by Pantoea agglomerans and their antioxidant activity
Biosynthesis of selenium nanoparticles by Pantoea agglomerans and their antioxidant activity
Insulin-Increased L-Arginine Transport Requires A(2A) Adenosine Receptors Activation in Human Umbilical Vein Endothelium
Insulin-increased L-arginine transport requires A(2A) adenosine receptors activation in human umbilical vein endothelium
L-Arginine Transport and Nitric Oxide Synthesis in Human Endothelial Progenitor Cells
L-arginine transport and nitric oxide synthesis in human endothelial progenitor cells
Fetal endothelium dysfunction is associated with circulating maternal levels of sE-selectin, sVCAM1, and sFlt-1 during pre-eclampsia.
Insulin Restores Gestational Diabetes Mellitus Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium
Insulin Restores Gestational Diabetes Mellitus-Reduced Adenosine Transport Involving Differential Expression of Insulin Receptor Isoforms in Human Umbilical Vein Endothelium
Insulin-stimulated L-arginine transport requires SLC7A1 gene expression and is associated with human umbilical vein relaxation
Insulin-Stimulated L-Arginine Transport Requires SLC7A1 Gene Expression and Is Associated With Human Umbilical Vein Relaxation
A role for insulin on L-arginine transport in fetal endothelial dysfunction in hyperglycaemia
A Role for Insulin on L-Arginine Transport in Fetal Endothelial Dysfunction in Hyperglycaemia
Reduced L-Arginine Transport and Nitric Oxide Synthesis in Human Umbilical Vein Endothelial Cells from Intrauterine Growth Restriction Pregnancies is Not Further Altered by Hypoxia
Reduced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelial cells from intrauterine growth restriction pregnancies is not further altered by hypoxia
High D-Glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium
High D-glucose reduces SLC29A1 promoter activity and adenosine transport involving specific protein 1 in human umbilical vein endothelium
Equilibrative nucleoside transporter 1 expression is downregulated by hypoxia in human umbilical vein endothelium
Equilibrative nucleoside transporter 2 is expressed in human umbilical vein endothelium, but is not involved in the inhibition of adenosine transport induced by hyperglycaemia
Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters 1 and 2, and membrane hyperpolarization in human umbilical vein endothelium
Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium

Abstract (9)

DIFFERENTIAL EXPRESSION OF CATALYTIC SUBUNITS OF NADPH OXIDASE IN HUMAN PLACENTA FROM GESTATIONAL DIABETES
DIFFERENTIAL EXPRESSION OF CHOP AND GADD34 IN HUMAN FETAL ENDOTHELIUM FROM GESTATIONAL DIABETES
GESTATIONAL DIABETES DECREASES TERMINAL VILLOUS VASCULATURE IN HUMAN PLACENTA
GESTATIONAL DIABETES DIFFERENTIALLY MODIFIES THYROID HORMONE TRANSPORTER EXPRESSION IN HUMAN PLACENTAL COTYLEDON
ROLE OF ENDOPLASMIC RETICULUM STRESS IN PLACENTAL VASCULAR DYSFUNCTION ASSOCIATED TO INSULIN RESISTANCE IN MATERNAL OBESITY.
CHRONIC INCUBATION WITH HIGH EXTRACELLULAR D-GLUCOSE INCREASES THE CONTRACTILITY OF HUMAN UMBILICAL VEIN RINGS
UMBILICAL VEIN ENDOTHELIUM ACTIVATION IS ASSOCIATED WITH HIGH MATERNAL LEVELS OF E-SELECTIN, VCAM-1 AND SFLT-1 IN SEVERE PRE-ECLAMPTIC PREGNANCIES
D-Glucose increases the expression and activity of hCAT-1 and Spl binding to SLC7A1 promoter in human umbilical vein endothelium
Maternal diabetes affects cell proliferation during placentation

BookSection (3)

Regulation of expression and activity of L-arginine transporters by nutrients and hormones: A focus in transcriptional mechanisms regulated by glucose and insulin
Fetoplacental vascular pathophysiology in preeclampsia
Maternal and fetal metabolic dysfunction in pregnancy diseases associated with vascular oxidative and nitrative stress

Patent (1)

PROCESO PARA OBTENER BIOLÓGICAMENTE NANOPARTÍCULAS DE SELENIO, ÚTILES EN LA SUPLEMENTACIÓN DIETARIA DE PERSONAS QUE PADECEN DEFICIENCIA DE SELENIO.

Proyecto (6)

Donut-shaped starch microparticles: preparation, characterization and applications
Caracterización de la expresión y actividad de hCATs, NADPH oxidasa y KCa en vasos sanguíneos de placenta humana proveniente de mujeres con diabetes gestacional.
Estudio de las alteraciones eléctricas y mecánicas de membrana plasmática de células endoteliales de vena umbilical humana en respuesta a la diabetes gestacional o condiciones estresantes relacionadas con la hiperglicemia.
Bio-obtención de nanopartículas de selenio encapsuladas en polisacáridos para su potencial uso como suplemento alimentario
Evaluation of novel technologies for the extraction, purification and stabilization of natural proanthocyanidins: functionalized as possible phytodrug
Regulation of expression and activity of hCAT-1 by reactive oxygen species in human endothelium exposed to insulin and high concentrations of D-glucose

Review (4)

Role of heme oxygenase 1 and human chorionic gonadotropin in pregnancy associated diseases
Cardiovascular Action of Insulin in Health and Disease: Endothelial L-Arginine Transport and Cardiac Voltage-Dependent Potassium Channels
Potential benefits of physical activity during pregnancy for the reduction of gestational diabetes prevalence and oxidative stress
Physiological mechanisms of vascular response induced by shear stress and effect of exercise in systemic and placental circulation
2
Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
CORALIA RIVAS

Associated Professor

Pathophysiology

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

2
Edgar Pastene

Profesor

Ciencias Básias

Universidad del Bío-Bío

Chillán, Chile

1
Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

8
Marcelo Farias

Assistant Professor

Division of Obstetrics and Gynecology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE OBSTETRICIA

Santiago, Chile

7
Claudio Aguayo

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

3
Liliana Lamperti

Vicedecana

UNIVERSIDAD DE CONCEPCIÓN, FACULTAD DE FARMACIA

Concepción, Chile

1
JORGE MORENO

Professor

Food Engineering

UNIVERSIDAD DEL BIOBIO

CHILLAN, Chile

1
Victor Campos

Associate Professor

Microbiology

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Felipe Zuñiga

Profesor Asociado

Bioquimica Clinica e Inmunologia

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Patricio Bertoglia

Profesor asistente

Ciencias Basicas y Clinicas

Universidad Católica de la Santisima Concepción

Chillan, Chile

42
Marcelo González

Profesor Asociado

Obstetricia y Ginecología

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Claudia Radojkovic

PROFESOR ASOCIADO

DEPTO. BIOQUÍMICA CLÍNICA E INMUNOLOGÍA, FAC. FARMACIA, UNIV. CONCEPCIÓN

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

3
Fabian Pardo

Profesor titular

Escuela de Medicina

Universidad de Valparaiso

San Felipe, Chile

7
Andrea Leiva

Profesor Asociado

Facultad de Ciencias de la Salud

Universidad San Sebastián

Santiago, Chile

1
Guillermo Petzold

Associate Professor

Departament of Food Engineering

UNIVERSIDAD DEL BÍO-BÍO

Chillan, Chile

3
Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

1
Maite Rodriguez

Jornada completa- Jefa de Carrera

Química

Universidad Tecnológica Metropolitana

Santiago, Chile

1
Alejandro Godoy

Associate Professor

Centro de Biología Celular y Biomedicina

Universidad San Sebastián

Santiago, Chile

4
Bernardo Krause

Associate Professor

Insituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

9
Carlos Escudero

Full Professor

Basic Sciences Department

Universidad del Bio Bio

Chillan, Chile

1
Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

2
Fernando Abarzua

medico staff

obstetricia

Hospital Hernan Henriquez Aravena

Temuco, Chile

15
LUIS SOBREVIA

Professor

Division of Obstetrics and Gynaecology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

3
Francisco Westermeier

Universidad de Chile

Santiago, Chile

1
Luis Guzman

Profesor Asistente

Departamento Bioquímica Clínica e Inmunohematología

UNIVERSIDAD DE TALCA

Talca, Chile

3
Carlos Salomón

Academic

University of Concepcion

Concepcion, Chile

8
Enrique Guzman

Profesor Asistente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

1
Pablo Torres

Profesor Asistente

Farmacia

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

1
Iván Rodríguez

Kinesiólogo

Programa AVNI

Ministerio de Salud

Talcahuano, Chile

1
MARIO SIMIRGIOTIS

full professor

Facultad de Ciencias

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

5
Paola Casanello

Profesor Asociado

División de Obstetricia y Ginecología

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Marcela Cid

PROFESOR ASISTENTE

OBSTETRICIA Y PUERICULTURA

UNIVERSIDAD DE CONCEPCION

CONCEPCION, Chile

1
Saddys Rodríguez

Investigador

Centro de Investigación de Polímeros Avanzados

Concepción, Chile

1
Erica Castro

Investigadora

Obstetricia y Puericultura

Universidad de Atacama

Copiapó, Chile

1
Solange Torres

Investigador Postdoctoral

Botánica

Universidad de Concepción

Concepción, Chile

3
Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

1
Constanza Sabando

Ingeniero de Proyecto

Investigación

Centro de Investigación de Polímeros Avanzados

Concepción, Chile

1
Walther Ide

Ingeniero de Proyecto

Investigación

Centro de Investigación de Polímeros Avanzados

Concepción, Chile

1
CATALINA PRIETO

Investigadora senior

Biología

Universidad de Chile

Santiago, Chile

1
VALERIA AGUILERA

BIOQUIMICO

LABORATORIO CLINICO

COMPLEJO ASISTENCIAL DR.VICTOR RIOS RUIZ LOS ANGELES

LOS ANGELES, Chile

1
Sebastián Dubo

Profesor Asociado

Kinesiología

Universidad de Concepción

Concpeción, Chile

1
natalia rodriguez

Matrona - Gestión y Análisis de Proceso Asistencial- Ginecología No GES

Servicio de Obstetricia y Ginecología

Hospital Clínico Herminda Martin

Chillán, Chile

1
Juan Araya

Profesor Asociado

Análisis Instrumental

Universidad de Concepción

Concepción, Chile

4
Carlos Veas

BIOQIUMICO

MEDICINA

HOSPITAL REGIONAL GUILLERMO GRANT BENAVENTE

CONCEPCION, Chile

1
Paula Honorato

Colaborador docente

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

1
Roxana Orrego

Docente

Bioquímica Clínica e Inmunohematología

Universidad de Talca

Talca, Chile

2
Sebastián Gutiérrez

Asistente de Investigación

Bioquímica Clínica e Inmunología

Universidad de Concepción

Concepción, Chile

1
Rebeca Bouza

Profesor asociado

Física y ciencias de la tierra

universidad de la coruna

Ferrol, España

2
Daniela Mennickent

Académica

Departamento de Ciencias Básicas

Universidad Católica de la Santísima Concepción

Concepción, Chile

1
Felipe Troncoso

Investigador

Ciencias Basicas

Universidad del Bío-Bío

Chillan, Chile

1
Roberto Villalobos

Académico

Facultad de Medicina

Universidad de Valparaíso

San Felipe, Chile